We received word in late December that a 2-year team grant involving Drs. Brian Chow (UBC), Michael Hildebrand (Carleton), Vivial Mushahwar (University of Alberta), and Eve Tsai (OHRI) was being funded by the Ontario Neurotrauma fund. This funding will allow our team to further pursue the use of spinal cord cell cultures derived from pig and from live human spinal cord tissue to devise improved treatments of spinal cord injury. We thank the Ontario Neurotrauma Fund for this tremendous opportunity. Please see this link for further information.
We co-organized with Dr. Eve Tsai from the OHRI, the inaugural Ottawa Spinal Cord and Brain Regeneration meeting held at the uOttawa Skills and Simulations Centre at the Civic Hospital. About 60 researchers and trainees attended the day event, which consisted of many stimulating talks describing the latest and most innovative research done in Ottawa looking into treating and assessing spinal cord injury and neurotrauma.
This was followed in the evening by a public event as part of the Brain Health Awareness Week organized by the uOttawa Brain and Mind Research Institute. Over 170 attendees heard from a panel consisting of Tuan, Dr. Mike Hildebrand, Dr. Andrew Pelling, Dr. Eve Tsai and Dr. Jing Wang about exciting research into treatment of spinal cord injury and neurotrauma.
Thanks to all of those who assisted and attended the events. Also, thanks to the generous support of the uOttawa Brain and Mind Research Institute, the Ontario Neurotrauma Fund, the OHRI, and the Bhargava family. It was a milestone day for spinal cord and brain regeneration research in Ottawa.
Tuan received an Early Researcher Award from the Ministry of Research and Innovation of Ontario. This $150,000 award will allow the lab to fund PhD students and to hire a postdoctoral fellow to study questions related to the recovery of movement following spinal cord injury.
It is thus with great pleasure that we welcome Ben Lindsey as a postdoctoral fellow to the lab. Ben completed his PhD in the lab of Vince Tropepe at the University of Toronto and followed this up with a short Postdoctoral fellow at Monash University under Jan Kaslin. We were able to convince him to move back to Ontario and to do a postdoctoral fellowship in the lab where his work on adult stem cells in zebrafish will be applied to spinal cord injury work in mammalian and fish models.
Yann received an award for best poster by a Senior PhD student at Brain Health Research Day for his poster looking at the involvement of glycine in the operation of spinal locomotor networks at different developmental stages of the zebrafish. Congratulations for a well-deserved award!
The lab is participating in the Lap the Gats fundraiser for Parkinson’s Research. Adib, Melissa and I will be biking through the beautiful Gatineau Park on June 25th. Please consider donating to this cause by going to https://www.crowdrise.com/TeamBuiLab
Several lab members presented their work at the 11th annual meeting of the Canadian Association for Neurosciences. These include Adib, Carl, David, and Yann. Well done
The arrival of the summer term also sees the welcome addition of three new lab members, Sara Goltash (PhD candidate), Nicolas Lalonde (Honours student), and MaryAnnWu (Honours student).
April 2017 (continued)
Congratulations to Kevin Amelete, Adib Dehghany, and Stefan Visentin for completing their Honours theses and for their poster presentations at the Department of Biology/BIM Honours Poster day. Thank you for your hard work and for representing the lab well
We have been awarded a NSERC Research Tools and Instrument grant valued at $141K to assemble an optogenetic platform for high-throughput interrogation of cellular basis of physiological function in zebrafish. Dr. Bui was the lead applicant, and his fellow co-applicants on this application were Drs. Marie-Andrée Akimenko, Marc Ekker, Kathleen Gilmour, Michael Jonz, Len Maler, Steve Perry, and Vance Trudeau. The equipment will allow all researchers involved to undertake research using optogenetics to answer important physiological questions using the zebrafish model.
Eugene Wang, Gerry Huynh, and Melissa Paradis presented their work at the University of Ottawa Undergraduate Research Opportunity Program (UROP) poster session. Congratulations on your hard work!
January 2017 (continued)
Our lab has been awarded a 150,000 CHF grant from the International Foundation for Research in Paraplegia (IRP)! We thank the IRP for their generosity and look forward to using this grant to continue our work aiming to developing advances in the treatment of lost motor function due to spinal cord injury.
Happy New Year to all. We wish you a fantastic 2017! To kick things off we have two events. First, Tuan will be giving a talk at the Neurosciences department of Carleton University on Friday January 6th at 10AM.
Secondly, and more importantly, Carl successfully defended his Master’s thesis on Monday January 9th. Congratulations we’re all very proud of you.
Big news! Tuan is a co-first author on a new article in the top-tier journal eLife. This study is the first to identify a population of spinal neurons that is important for the recovery of locomotion following a complete spinal cord injury in mice. Read the press release from uOttawa http://media.uottawa.ca/news/uottawa-researcher-discovers-new-lead-in-treating-spinal-cord-injuries
eLife is open access and the article can be found at the following DOI
Congratulations to Gerry Huynh, Melissa Paradis, and Eugene Wang on being awarded the Undergraduate Research Opportunity Program of the University of Ottawa. We all look forward to your many contributions to our research endeavours.
The Bui Lab is participating in two fundraising efforts over the next couple of weekends to support research into a couple of neurodegenerative disorders that affects many individuals worldwide.
The first is a fundraising effort to further research into Parkinson’s Disease called Lap the Gats organized by the Parkinson Research Consortium of the University of Ottawa.Adib and I will be cycling several(?) 21K loops for 3 hours through Gatineau Park on June 19th. Eugene is volunteering to help the event go smoothly.
If you are interested in donating, please visit our fundraiser page at http://www.crowdrise.com/NeuralMotorControlLab
The second fundraiser is a walk for Amyotrophic Lateral Sclerosis held in Ottawa, on June 12th. A few of the Bui Lab members will be making the walk
If you are interested in donating to this cause, please visit the page of the Centre for Neuromuscular Disorders, of which we are a part of: http://www.alsevents.ca/uOttawaCNMD
Thanks for reading
There are new faces joining the lab this summer. Stefan Visentin, Eugene Wang, and David Zheng are undergraduate students that will be pushing the lab forward in new and exciting directions. Welcome!
With the end of the school year, we also have to sadly say goodbye to our honours students, Jun Yu Gao, Diana Liu, and Saif Zemourra. Thank you for your involvement in the research endeavours of the lab and best of luck with your future careers.
For World Parkinson’s Disease Day, Tuan discussed recent progress in the fight against Parkinson’s Disease on a panel on the radio show Les malins plaisirs on CBC Radio Canada. A recording of the broadcast can be found at http://ici.radio-canada.ca/emissions/les_malins_plaisirs/2015-2016/ under Vivre avec le Parkinson 2016
Tuan will be participating in a parallel symposium at the annual meeting of the Canadian Association for Neuroscience in Toronto on May 30, 1:30-3PM. The session, entitled “Low-level circuits for sophisticated sensorimotor control: lessons from four model systems”, is organized by Andrew Pruszynski (Western) and will also feature Katherine Nagel (NYU) and Michael Hendricks (McGill).
Yann Roussel, Carl Farah, and Adib Dehghany from the lab will also be presenting posters at this meeting describing their latest research findings.
Congratulations to Mary Lynn Cottee, Adib Dehghany, Uyen Do, and Johnny Di Rienzo on being laureates of the Undergraduate Research Opportunity Program of the University of Ottawa. The lab looks forward to your participation in our various research endeavours.
Carl Farah is a co-author on a recently accepted review to be published in the Journal of Neurophysiology. Genetically identified spinal interneurons integrating tactile afferents for motor control provides a comprehensive overview of the latest findings on how spinal neurons process sensory information related to touch to shape motor output.
Yann Roussel is a co-author on a Perspective on decision making in escape responses. Choosing sides: making decisions in an escape response is published in the Journal of Physiology.
A manuscript entitled Spinal circuits for motor learning, written by Brownstone RM, Bui TV, and Stifani N, has been recently published in Current Opinion in Neurobiology as part of a themed issue on Motor Circuits and Actions.
Congratulations to Diana Liu who was awarded a summer research scholarship from the Faculty of Science at the University of Ottawa! This award will allow her to pursue work in collaboration with Dr. Diane Legace (University of Ottawa) investigating the involvement of spinal cord circuitry in recovery from stroke.
In addition, an application entitled Dissection of the Circuitry Involved in Activity-Induced Stroke Recovery to the Canadian Partnership for Stroke Recovery has been successfully funded. This application was spearheaded by Diane Legacé and includes Tuan and Dr. Jean-Claude Béïque as co-applicants (University of Ottawa).
Tuan’s grant application to the NSERC Discovery Grants program entitled “Neural Control of Swimming in Zebrafish” was successfully funded from 2015 to 2020!
Congratulations to Jun Yu Gao who was awarded a NSERC Undergraduate Summer Research Award! This award will allow her to pursue work in our lab characterizing a new class of spinal neurons in zebrafish.
Our manuscript entitled Sensory-evoked perturbations of locomotor activity by sparse sensory input: A computational study has been accepted by the Journal of Neurophysiology and is currently in press.
Tuan is giving a talk at the Scientific launch of the Centre for Neuromuscular Diseases. It is happening on October 26th at the Main Auditorium of the General Campus of the Ottawa Hospital. He will be speaking of his work on dI3 interneurons and their involvement in hand control and locomotion.
Renovations to our lab were completed this summer and we officially opened for business (research that is) in July! Now for the fun part – unpacking equipment and supplies out of boxes and setting everything up.